Characteristics and management of early breast cancer in elderly women assisted in the Mastology Care Teaching Unit of the Hospital de Clínicas in the period 2011- 2018
Abstract
Introduction: There are few guidelines for the treatment of breast
cancer (BC) in older patients, which can lead to under- or overtreatment.
Objective: To understand the characteristics, management and
evolution of early BC in older women.
Material and methods: Observational, descriptive, cross-sectional
study. Data were collected on the clinical-pathological characteristics
and evolution of patients aged 70 years or over treated for BC in the
period from 1/1/ 2011 to 31/12/ 2018, attended at the Hospital de
Clínicas. Descriptive statistical tools were used and the Kaplan-Meier method was used to calculate the overall survival (OS) rate.
Results: 31 patients were included; median age at diagnosis was
76.8 years old; the clinical-pathological characteristics were: ductal
carcinoma: 71%; HG 1-2: 74.2%; stage I: 54.8%; no axillary metastases:
80.6%; HER2-ER/PR+ 80.6%; HER2+ 16.7%, and triple negative 3.2%.
Twenty-nine patients were diagnosed through screening and 74.2%
were treated according to current guidelines, while 38.7% were
under-treated and 16.1% over-treated. The median OS was 98.7
months.
Conclusions: A minority of patients were diagnosed by screening,
the most frequent histological type was ductal and the prevalence
of HER2-RE/RP+ tumours was higher than in younger patients. Most
patients received standard treatment
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Copyright (c) 2021 Natalia Camejo, Cecilia Castillo, Ana Laura Hernández, Vanira Bárcena, Camila Goldman, Santiago González, María Paz Icardo, Martina Abero, Thaís Arenas, Lucia Delgado
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