Discomfort assessment by heart rate variability automatic detection in neonates and a newborn piglet model
Abstract
The objective and reproducible assessment of pain in neonates is a challenge in daily clinical practice and has short- and long-term consequences. The objective of this research is to assess
discomfort in a newborn pig model and newborn humans exposed to nociceptive maneuvers, using a non-invasive technology for evaluating heart rate variability (Newborn Infant Parasympathetic Evaluation) in the maternity ward of the Hospital Universitario. An observational study was conducted in 6 newborn piglets undergoing major surgery and 12 minimally invasive maneuvers in 8 healthy term newborns. Heart rate variability was compared with a validated acute pain assessment scale, widely used clinically in neonates (Premature Infant Pain Profile), and with heart rate average?. A negative correlation was found between heart rate and Newborn Infant Parasympathetic Evaluation, both for the group of human neonates (r=-1;p=0.008) and for the
animal model (r=-0.6;p=0.0004). No significant association was found between the Newborn Infant Parasympathetic Evaluation and the Premature Infant Pain Profile scale. It was shown that
the changes in heart rate are related to the Newborn Infant Parasympathetic Evaluation values.
Through this study we can conclude that the values of this new tool are correlated with the painful stimulus and at the same time with the heart rate. Further research is A larger number of
studies are required to confirm these findings in different clinical settings.
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Copyright (c) 2023 Lucas Da Luz, Anna Favale, Paula Jaureguy, Sofía Mederos, Victoria Mena, Esteban Ricca, Pilar Abella, Martín Badía, Fernanda Blasina, Tamara Cabral, Lucía Farías, Cecilia Fernández, Natalie González, Lucía Vaamonde
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