Survival of glottic cancer in the initial stage in 4 hospital centers in Uruguay
Abstract
Introduction: Laryngeal cancer is the most prevalent malignant tumor in Otorhinolaryngology. Glottic topography is the most frequent in Uruguay and is usually detected in early stages given the early and sustained manifestation of dysphonia. The objective of this study is to analyze disease-free survival (DFS) and overall survival (OS) of patients with stage T1N0M0 glottic laryngeal cancer at 4 institutions in Montevideo. Methodology: The mean OS and DFS of 55 patients diagnosed with T1 glottic cancer between 2009 and 2019 were retrospectively analyzed. Kaplan-Meier method was used to calculate survival. The prognostic effect of
certain variables of interest on OS was also studied using univariate and multivariate analysis.
Results: In this study, mean odds survival (OS) for T1N0M0 glottic cancer was 7.706 years (CI 95% 6.63 - 8.78).
At 5 years, OS was 77.5% (± 7%) and at 10 years was 62% (± 9.8%). Disease free survival (DFS) was 74.6% ±
(7.5%) at 5 years and 63.1% (± 9.8%), at 10 years. Median OS and DFS for the groups were not reached.
Conclusions: OS and DFS in our medium is comparable to that reported in the international literature. The median OS and DFS were not reached, so it can be stated that this disease has, when appropriate treatment is performed, a good vital prognosis at 10 years. Longer follow-up is required to determine the median OS and DFS of the study groups.
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References
Megwalu UC, Panossian H. Survival Outcomes in Early Stage Laryngeal Cancer. Anticancer Res. 2016;36(6):2903-2907.
Escajadillo J. Oídos, nariz, garganta y cirugía de cabeza y cuello. 2ª ed. México, El Manual Moderno, 2002.
Baird BJ, Sung CK, Beadle BM, Divi V. Treatment of early-stage laryngeal cancer: A comparison of treatment options. Oral Oncol. 2018;87:8-16. doi:10.1016/j.oraloncology.2018.09.012
De Stefani E, Boffetta P, Deneo-Pellegrini H, et al. Supraglottic and glottic carcinomas: epidemiologically distinct entities?. Int J Cancer. 2004;112(6):1065-1071. doi:10.1002/ijc.20501
De Stefani E, Boffetta P, Ronco AL, Deneo-Pellegrini H, Acosta G, Mendilaharsu M. Dietary patterns and risk of laryngeal cancer: an exploratory factor analysis in Uruguayan men. Int J Cancer. 2007;121(5):1086-1091. doi:10.1002/ijc.22765
Zbären P, Nuyens M, Curschmann J, Stauffer E. Histologic characteristics and tumor spread of recurrent glottic carcinoma: analysis on whole-organ sections and comparison with tumor spread of primary glottic carcinomas. Head Neck. 2007;29(1):26-32. doi:10.1002/hed.20502
Barrios E, Garau M, Alonso R, Musetti C. V Atlas de Incidencia del Cáncer en el Uruguay. Periodo 2012-2016 (Internet). Montevideo: Comisión Honoraria de Lucha Contra el Cáncer , 2020. Disponible en: https://www.comisioncancer.org.uy/Ocultas/V-Atlas-de-Incidencia-del-Cancer-enel- Uruguay-Periodo-2012-2016-uc250. Citado el 16/01/2021.
Guimarães AV, Dedivitis RA, Matos LL, Aires FT, Cernea CR. Comparison between transoral laser surgery and radiotherapy in the treatment of early glottic cancer: A systematic review and meta-analysis. Sci Rep. 2018;8(1):11900. doi:10.1038/s41598-018-30218-x
Uruguay. Poder Judicial. Decreto de Ley Nº 379/008. Investigaciones con seres humanos. Diario Oficial nº 27547 (14 agosto 2008):415-A
Uruguay. Poder Judicial. Ley No 18.331. Protección de datos personales y acción de "Habeas Data". Diario Oficial nº 27549 (18 agosto 2008):437-A.
Cellai E, Frata P, Magrini SM, et al. Radical radiotherapy for early glottic cancer: Results in a series of 1087 patients from two Italian radiation oncology centers. I. The case of T1N0 disease. Int J Radiat Oncol Biol Phys. 2005; 63(5):1378-1386. doi:10.1016/j.ijrobp.2005.05.018
Canis M, IhlerF, Martin A, Matthias C, Steiner W. Transoral lasermicrosurgery for T1a glottic cancer: review of 404 cases. Head Neck. 2015; 37(6):889-895. doi:10.1002/hed.23688
Adeel M, Faisal M, Rashid A, et al. Outcomes of definitive radiotherapy for early laryngeal cancer in terms of survival and patterns of failure. J Laryngol Otol. 2019; 133(12):1087-1091. doi:10.1017/S0022215119002433
Al-Mamgani A, van Rooij PH, Woutersen DP, et al. Radiotherapy for T1-2N0 glottic cancer: a multivariate analysis of predictive factors for the longterm outcome in 1050 patients and a prospective assessment of quality of
life and voice handicap index in a subset of 233 patients. Clin Otolaryngol. 2013; 38(4):306-312. doi:10.1111/coa.12139
Warner L, Chudasama J, Kelly CG, et al. Radiotherapy versus open surgery versus endolaryngeal surgery (with or without laser) for early laryngeal squamous cell cancer. Cochrane Database Syst Rev. 2014;2014(12):CD002027. Doi:10.1002/14651858.CD002027.pub2
Cheraghlou S, Kuo P, Judson BL. Treatment delay and facility case volume are associated with survival in early-stage glottic cancer. Laryngoscope. 2017; 127(3):616-622. doi:10.1002/lary.26259
Chen AY, Pavluck A, Halpern M, Ward E. Impact of treating facilities' volume on survival for early-stage laryngeal cancer. Head Neck. 2009;31(9):1137-1143. doi:10.1002/hed.21072
Porras Alonso E, Vilaseca González I, García Teno M, et al. Tumores glóticos precoces con afectación de la comisura anterior. Revisión bibliográfica y documento de consenso. Comisión de cabeza y cuello y base de cráneo. SEORL-CCC. Acta Otorrinolaringológica Española 2020. doi:10.1016/ j.otorri.2020.02.008
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