Gelatinases as Markers of Chronic Alcohol Consumption:

A Pilot Study in Uruguay

  • Marta Marco Facultad de Medicina. Universidad de la República
  • Daniela Boragno
  • Paola Rodríguez Facultad de Medicina. Universidad de la República
  • Victoria Mestre Cordero
  • Natalia Pereira Facultad de Medicina. Universidad de la República
  • Patricia Berasain Facultad de Medicina. Universidad de la República
  • Florencia Cadenas
  • Cecilia Rodríguez Rodríguez Facultad de Medicina. Universidad de la República
  • Alejandra Moreira Facultad de Medicina. Universidad de la República
DOI: https://doi.org/10.25184/anfamed2020v7n1a3
Keywords: Gelatinases

Abstract

Chronic alcohol consumption in Uruguay is a growing problem, however, determinations of consensual biomarker are not performed systematically neither potential markers are explored. To validate the hypothesis that matrix metalloproteinases with gelatinase activity are biomarkers of chronic alcohol consumption, blood samples of 100 alcoholics that began medical treatment at the Unidad de Trastornos
Relacionados con el Alcohol and 50 healthy non-alcoholic donors were evaluated. Alcoholic samples showed gelatinase activity that tripled that of controls and small but significant increases in levels of gamma-glutamyl transferase, aspartate-aminotransferase and mean cellular volume. Carbohydrate deficient transferrin values were lower in alcoholics than in controls. These results allow proposing gelatinases as the most sensitive indicators of sustained alcohol consumption in the population analyzed since hepatic enzymes and mean cellular volume showed a tendency consistent with the literature but did not reach values associated with the
pathology. Since carbohydrate-deficient transferrin is considered the most sensitive and specific indirect biomarker of chronic alcohol consumption, lower values in alcoholics related to controls suggest methodological problems that could be solved by applying other measurement techniques or the presence of yet unknown interferences. Finally, these findings justify an extension of this pilot work, as well as additional studies focused on the participation of matrix metalloproteinases with gelatinase activity in the cascades of damage associated with chronic alcohol consumption.

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Author Biography

Marta Marco, Facultad de Medicina. Universidad de la República

Laboratorio de Biología Tumoral, Departamento de Bioquímica Clínica, Facultad de Química, Universidad de la República, Uruguay.

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Published
2020-05-10
How to Cite
Marco, M., Boragno, D., Rodríguez, P., Mestre Cordero, V., Pereira, N., Berasain, P., Cadenas, F., Rodríguez, C. R., & Moreira, A. (2020). Gelatinases as Markers of Chronic Alcohol Consumption:: A Pilot Study in Uruguay. Anales De La Facultad De Medicina, 7(1), e2020v7n1a3. https://doi.org/10.25184/anfamed2020v7n1a3
Issue
Vol. 7 No. 1 (2020): Anales de la Facultad de Medicina
Section
Artículos originales

Copyright (c) 2020 Marta Marco, Daniela Boragno, Paola Rodríguez, Victoria Mestre Cordero, Natalia Pereira, Patricia Berasain, Florencia Cadenas, Cecilia Rodríguez Rodríguez, Alejandra Moreira

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